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Rickets and Vitamin D Deficiency in Alaska Native Children
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7 2015
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Source: J Pediatr Endocrinol Metab. 28(0):815-823
[PDF-353.43 KB]
Details:
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Alternative Title:J Pediatr Endocrinol Metab
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Personal Author:
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Description:Background
Rickets and vitamin D deficiency appeared to increase in Alaskan children, starting in the 1990s. We evaluated the epidemiology of rickets and vitamin D deficiency in Alaska Native (AN) children in 2001-2010.
Methods
We analyzed 2001-2010 visits with rickets or vitamin D deficiency diagnosis for AN and American Indian children and the general U.S. population aged <10 years. We conducted a case-control study of AN rickets/vitamin D deficient cases and age- and region-matched controls.
Results
AN children annual rickets-associated hospitalization rate (2.23/100,000 children/year) was higher than general U.S. rate (1.23; 95% CI 1.08-1.39). Rickets incidence increased with latitude. Rickets/vitamin D deficiency cases were more likely to have malnutrition (OR 38.1; 95% CI 4.9-294), had similar breastfeeding prevalence, and were less likely to have received vitamin D supplementation (OR 0.23; 95% CI 0.1-0.87), than controls.
Conclusions
Our findings highlight the importance of latitude, malnutrition and lack of vitamin D supplementation as risk factors for rickets.
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Pubmed ID:25741788
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Pubmed Central ID:PMC4678029
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Volume:28
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Issue:0
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